Novel alcohol dehydrogenases for the synthesis of chiral alcohols

Id:
4

Funder:
Environmental Protection Agency

Title:
Novel alcohol dehydrogenases for the synthesis of chiral alcohols

Coordinator:
Paradisi Francesca

Organisation:
University College Dublin (UCD)

Country:
IRELAND

SRIA Themes:
{sriathemes}

Start Date:
04/09/2006

End Date:
05/01/2011

Summary:
Enzymes from extremophiles (organisms which live in extreme environments) have unusual characteristics of stability and tolerance to harsh working reaction conditions making them extremely appealing for bio-applications and industrial scale-ups. The aim of this project is to clone an alcohol dehydrogenase (ADH) from Halobacterium salinarum an archaebacterium which thrives in highly-salted water to investigate its properties. ADHs can reduce ketones to secondary chiral alcohols which together with their derivatives are in great demand from the pharmaceutical industry. This project targets the production of valuable molecules via bio-catalysis employing a robust biocatalyst (enzyme) with minimal impact on the environment (green chemistry).

Keywords:
Enzymes; Pharmaceutical Industry; Tolerance; Green Chemistry